Abouzid, Khaled

khaled.abouzid@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Anticancer drug discovery, design and synthesis, Antimicrobial,
Internal ID: rp12178
  • 2,885 Scopus Citations
  • 592 PubMed Citations

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Full Name
Abouzid, Khaled
 
 
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Biography
Dr. Khaled Abouzid is a Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Prominent Scholar in Drug Discovery, Co-founding Director of Center of Drug Discovery and Development Research ASU He was nominated as the Acting Dean of the Faculty of Pharmacy, University of Sadat City from 8-2018 to 8-2022. He is currently a member of national pharmaceutical chemistry promotion committee
Dr. Abouzid’s research is directed towards drug discovery of bioactive small molecules with special emphasis on cannabinoids, targeted anticancer, anti-inflammatory, anti-viral anti-microbial agents and enzyme inhibitors. He has published over 150 research papers, two books and filed 14 patents in medicinal chemistry. He has Scopus H index of 28. He has supervised over 100 Master and PhD students in 7 universities. Dr Abouzid has research collaborations with German, British, Swedish, Canadian and US universities. He has also organized and presided over 34 international symposia and conferences.
Dr. Abouzid obtained his B.Sc. degree in Pharmaceutical Sciences from Cairo University in 1985, and his PhD. joint degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University and School of Pharmacy University of Connecticut, USA.
Dr. Abouzid started his career in 1995 as a lecturer of Organic Chemistry at Cairo University, Faculty of Pharmacy. In 2001, he moved to the Department of Pharmaceutical Chemistry, Ain Shams University, and was promoted to Associate Professor in 2003. He did postdoctoral work with Professor Jochen Lehman of the Friedrich-Schiller-Universität Jena, Germany.

Publications

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Issue DateTitleAuthor(s)
127-Nov-2012Applying Ligands Profiling Using Multiple Extended Electron Distribution Based Field Templates and Feature Trees Similarity Searching in the Discovery of New Generation of Urea-Based Antineoplastic Kinase InhibitorsDokla, Eman ; Mahmoud, Amr H.; Elsayed, Mohamed S.A.; El-Khatib, Ahmed H.; Linscheid, Michael W.; Khaled A M Abouzid 
2Dec-2012Virtual screening and synthesis of new chemical scaffolds as VEGFR-2 kinase inhibitorsEl-Araby, M E; Serya, Rabah ; Elbarbary, Elsayed M.E.; Khaled A M Abouzid 
3Mar-2013Assessment of new anti-HER2 ligands using combined docking, QM/MM scoring and MD simulationAhmed, Marawan; Sadek, Maiada M; Serya, Rabah ; Kafafy, Abdel-Hamid N; Wang, Feng; Khaled A M Abouzid 
4Mar-2013Structure-based design and synthesis of novel pseudosaccharine derivatives as antiproliferative agents and kinase inhibitorsElsayed, Mohamed S A; El-Araby, Moustafa E; Serya, Rabah ; El-Khatib, Ahmed H; Linscheid, Michael W; Khaled A M Abouzid 
51-Dec-2013Ligand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino] phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino- acetamidobenzoic acid estersIsmail, Mohamed Abdel Hamid; Mohamed, Nasser Saad; Dokla, Eman ; Khaled A M Abouzid 
6Apr-2014Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agentsSadek, Maiada M; Serya, Rabah ; Kafafy, Abdel-Hamid N; Ahmed, Marawan; Wang, Feng; Khaled A M Abouzid 
7Jun-2014Molecular design and synthesis of 1,4-disubstituted piperazines as α(1)-adrenergic receptor blockersHussein, Mohammed M; Serya, Rabah ; Abdel Naby, Rana M; Al-Abd, Ahmed M; Saleh, Dalia O; El-Eraky, Wafaa I; Khaled A M Abouzid ; Abou El Ella, Dalal 
8Dec-2014Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agentsAbdel-Atty, Mona M; Farag, Nahla A; Kassab, Shaymaa E; Serya, Rabah ; Khaled A M Abouzid 
92015Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivativesAbdou, Nermin S.; Serya, Rabah ; Esmat, Ahmed ; Tolba, Mai F.; Ismail, Nasser S. M.; Khaled A M Abouzid 
10Nov-2015Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) ActivatorsFang, Chun-Sheng; Lai, Po-Ting; Kulp, Samuel K; Serya, Rabah ; Ismail, Nasser S M; Chen, Ching-Shih; Dokla, Eman ; Khaled A M Abouzid 
1115-Apr-2016Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting AgentsAziz, Marwa A; Serya, Rabah A T; Lasheen, Deena S. ; Abdel-Aziz, Amal Kamal ; Mansour, Ahmed M; Ahmed Esmat ; Singab A. ; Khaled A M Abouzid 
1230-Jan-2017Click and Release: SO2 Prodrugs with Tunable Release RatesSerya, Rabah ; Khaled A.M.abouzid; Deena S.Lasheen; Xingyue Ji; Binghe Wang; Khaled A M Abouzid 
1315-Dec-2017How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitorsMilik, Sandra N; Lasheen, Deena S; Serya, Rabah ; Abouzid, Khaled A M; Khaled A M Abouzid 
1425-May-2018Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogensElAwamy, Moustafa; Mohammad, Haroon; Hussien, Abdelrahman; Abutaleb, Nader S; Hagras, Mohamed; Serya, Rabah ; Taher, Azza T; Seleem, Mohamed N; Mayhoub, Abdelrahman S; Khaled A M Abouzid 
1515-Jul-2018Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitorsMilik, Sandra N; Abdel-Aziz, Amal Kamal; Serya, Rabah ; Minucci, Saverio; Lasheen, Deena S. ; Khaled A M Abouzid 
16Dec-2018Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modelingAdel, Mai; Serya, Rabah ; Lasheen, Deena S. ; Khaled A M Abouzid 
172019Identification of novel pyrazole and benzimidazole based derivatives as PBP2a inhibitors: Design, synthesis, and biological evaluationShalaby, Menna-Allah; Dokla, Eman ; Serya, Rabah ; Abouzid, Khaled 
182019Design, synthesis and molecular docking of novel pyrazolo[1,5-a][1,3,5]triazine derivatives as CDK2 inhibitorsOudah, Khulood H; Najm, Mazin A A; Samir, Nermin; Serya, Rabah ; Khaled A M Abouzid 
192019Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activityElsayed, Nevine M Y; Serya, Rabah ; Tolba, Mai ; Ahmed, Marawan; Barakat, Khaled; Abou El Ella, Dalal ; Khaled A M Abouzid 
2015-Nov-20191,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLCDokla, Eman ; Fang, Chun Sheng; Chen, Ching S.; Abouzid, Khaled