Ahmed Esmat

ahmed.esmat@pharma.asu.edu.eg

Department of Pharmacology and Toxicology - Pharmacy
Interests: Bioactivation and mechanisms of chemically-induced toxicity, Oxidative stress-mediated cellular injury and protective antioxidant mechanisms, Susceptibility to drugs and chemical toxicity, Anti-inflammatory activity of natural and synthetic chemicals,
Internal ID: rp11912
  • 1,440 Scopus Citations
  • 349 PubMed Citations

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Full Name
Ahmed Esmat
 
 
 
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Biography
EDUCATION:
May 2002: Bachelor’s degree in Pharmaceutical Sciences, Ain-Shams University, Egypt, with the first rank over 366 students in my class.
September 2007: Master’s degree in Pharmaceutical Sciences (Pharmacology and Toxicology), Ain-Shams University, Egypt. Title: Evaluation of Nitrile(s) Toxicity on Rat Brain.
July 2008: International Computer Driving License (ICDL), Syllabus Version (4), endorsed by Ministry of Communications and Information Technology – Egypt, with the support of UNESCO.
August 2008: Test Of English as Foreign Language, internet Based Test (TOEFL iBT), score 101/120
October 2012: Ph.D. Pharmacology and Toxicology, Ain Shams University and The Ohio State University, Columbus, Ohio, USA (under the channel system and joint supervision scheme). Title: Developmental and Neurotoxicological Effects of Water Disinfection Byproduct(s) in Experimental Animals.

OCCUPATIONAL BACKGROUND:
September 2017 – present: Seconded Associate Professor, Department of Pharmacology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
January 2018 – present: Associate Professor, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
February 2017 – June 2017: (Part-time) Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni Suef, Egypt.
August 2015 – June 2016: (Part-time) Lecturer of Pharmacology and Toxicology, Technical Institute of Nursing, Egyptian Armed Forces, Egypt.
September 2013 – June 2015: (Part-time) Lecturer of Pharmacology and Toxicology, Faculty of Pharmacy, Misr International University (MIU), El-Obour city, Egypt.
November 2012 – December 2017: Lecturer, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
May 2012 – October 2012: Assistant lecturer, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
April 2011 – April 2012: Visiting Scholar, Center for Environmental and Smoking-Induced Diseases, Davis Heart & Lung Research Institute (DHLRI), Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
November 2007 – March 2011: Assistant lecturer, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
January 2003 – October 2007: Demonstrator, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

HONOURS:
March 2022 – present: Editor at “Egyptian Journal of Basic and Clinical Pharmacology”
March 2022: Contribution in The Multiple Mini Interview (MMI) 2022, division of Academic Counselling & Student Support Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
November 16th, 2021: United States Patent; 11,174,233 B1 on the invention known as “Anticancer compounds having oxazolone derivation”.
November 13th, 2021: United States Patent; 11,180,458 B2 on the invention known as ““Anticancer compounds, pharmaceutical compositions thereof and a method of treating cancer”.
October 2021 - present: Reviewer Editor at Frontiers in Pharmacology -Ethnopharmacology.
October 2021: Abstract Reviewer for the international conference “Knowledge, Skill, & Ability in Pharmacy & Toxicology” (KSAPT) 2021; held by “Saudi Pharmaceutical Society”.
August 2021: Contribution in The Multiple Mini Interview (MMI) 2021, division of Academic Counselling & Student Support Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
April 2015 – September 2017: Technical Manager of Experimental Advanced Pharmaceutical Research Unit “EAPRU”, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
November 2013 – November 2017: Co-investigator in the project “Drug discovery and development research” ID: 5251, Type “Center of Excellence”, funded by STDF, Ministry of Scientific Research, Egypt.
April 2011 – April 2012: Scientific Mission to the Ohio State University, Columbus, Ohio, USA; awarded by the Egyptian Ministry of High Education and supported by the Egyptian Government according to the Channel System and Joint Supervision Scheme.

Reviewer at the following journals:
1. Arabian Journal of Chemistry
2. Archives of Medical research
3. Archives of Pharmaceutical Sciences - Ain Shams University
4. Bioorganic Chemistry
5. BMC Complementary Medicine and Therapies
6. Cellular signaling
7. Drug and Chemical Toxicology
8. Egyptian Journal of Basic and Applied Sciences
9. Egyptian Journal of Basic and Clinical Pharmacology
10. Frontiers in Pharmacology
11. Journal of Applied Toxicology
12. Journal of Ethnopharmacology
13. Journal of Functional Food
14. Journal of King Abdulaziz University-Medical Sciences
15. Life Sciences
16. Pharmacological Reports
17. Phytotherapy Research
18. Plants
19. Plos One
20. Reproductive Biology
21. Saudi Journal of biological sciences
22. Scientific Reports
23. The science of nature
24. Toxicology and Industrial Health

Contribution in “Establishment of an Internal Quality Assurance System” as one of the “Quality Assurance and Accreditation Projects (QAAP) of higher education in Egypt (2006-2007), performing the following roles:
1. Preparing all course specifications and reports belonging to Pharmacology department, Faculty of Pharmacy, Ain Shams University
2. Preparing the specification and report of the educational program “Bachelor of Pharmaceutical Sciences”

Contribution in “Continuous Improvement for Qualification & Accreditation Project (CIQAP) of higher education in Egypt (2008-2010), in Educational Programs Criterion that involved annual preparation and revision of all specifications and reports concerning all under- and postgraduate programs:
1. Bachelor of Pharmaceutical sciences program
2. Bachelor of Pharmaceutical sciences and drug design program
3. Diploma of Clinical Pharmacy
4. Master programs of all Faculty departments
5. Ph.D. programs of all Faculty departments

April - September 2017: Member of the scientific committee responsible for evaluation of preclinical studies for pharmaceutical products in National Organization for Drug and Control Research, Egypt (NODCAR).

Publications

Results 21-40 of 45 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
211-Feb-2018Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivoSobeh, Mansour; Ahmed Esmat ; Petruk, Ganna; Abdelfattah, Mohamed A.O.; Dmirieh, Malak; Monti, Daria Maria; Abdel-Naim, Ashraf B.; Wink, Michael
2220-Jan-2018Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activityHossam, Monia; Ahmed Esmat ; Mansour, Ahmed M; Abouzid, Khaled A M; Singab A. 
235-Jan-2018In vivo cellular and molecular gastroprotective mechanisms of chrysin; Emphasis on oxidative stress, inflammation and angiogenesisAhmed Esmat ; Tadros, Mariane G.; El-Demerdash, Ebtehal; George, Mina Y. 
241-Jan-20182-Methoxyestradiol attenuates testosterone-induced benign prostate hyperplasia in rats through inhibition of HIF-1 α /TGF- β /Smad2 AxisAbdel-Naim, Ashraf B.; Neamatallah, Thikryat; Eid, Basma G.; Ahmed Esmat ; Alamoudi, Abdulmohsin J.; Abd El-Aziz, Gamal S.; Ashour, Osama M.
251-Jan-2018Chrysin attenuates testosterone-induced benign prostate hyperplasia in ratsShoieb, Sherif M.; Ahmed Esmat ; Khalifa, Amani E.; Abdel-Naim, Ashraf B.
261-Dec-2017Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activityAly, Rasha M.; Serya, Rabah ; El-Motwally, Amira M.; Abbas, Safinaz; Abou El Ella, Dalal ; Esmat, Ahmed 
271-Dec-2017Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathwaysMantawy, Eman M.; Ahmed Esmat ; El-Bakly, Wesam M.; Salah Eldin, Rania A.; El-Demerdash, Ebtehal
281-May-2017Aloe arborescens polysaccharides: In vitro immunomodulation and potential cytotoxic activityNazeam, Jilan A.; Gad, Haidy A.; Ahmed Esmat ; El-Hefnawy, Hala M.; Singab, Abdel Naser B.
291-Feb-2017Telmisartan ameliorates carbon tetrachloride-induced acute hepatotoxicity in ratsAtawia, Reem T.; Ahmed Esmat ; Elsherbiny, Doaa A.; El-Demerdash, Ebtehal
301-Jun-2016Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatumMenze, Esther T.; Ahmed Esmat ; Tadros, Mariane G.; Khalifa, Amani E.; Abdel-Naim, Ashraf B.
3115-Apr-2016Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting AgentsAziz, Marwa A; Serya, Rabah A T; Lasheen, Deena S. ; Abdel-Aziz, Amal Kamal ; Mansour, Ahmed M; Ahmed Esmat ; Singab A. ; Khaled A M Abouzid 
3224-Dec-2015Anti-inflammatory sesquiterpenes from Costus speciosus rhizomesAl-Attas, Ahmed A.M.; El-Shaer, Nagwa S.; Mohamed, Gamal A.; Ibrahim, Sabrin R.M.; Ahmed Esmat 
331-Dec-2015A Systemic Review on Aloe arborescens Pharmacological Profile: Biological Activities and Pilot Clinical TrialsSingab, Abdel Naser B.; El-Hefnawy, Hala M.; Ahmed Esmat ; Gad, Haidy A.; Nazeam, Jilan A.
3423-Oct-2015Metformin Attenuates Testosterone-Induced Prostatic Hyperplasia in Rats: A Pharmacological PerspectiveMosli, Hala H.; Ahmed Esmat ; Atawia, Reem T.; Shoieb, Sherif M.; Mosli, Hisham A.; Abdel-Naim, Ashraf B.
353-Jun-2015Anti-inflammatory activity of flavonoids from Chrozophora tinctoriaAbdallah, Hossam M.; Almowallad, Fahad M.; Ahmed Esmat ; Shehata, Ibrahim A.; Abdel-Sattar, Essam A.
3612-Feb-2015Genistein improves 3-NPA-induced memory impairment in ovariectomized rats: Impact of its antioxidant, anti-inflammatory and acetylcholinesterase modulatory propertiesMenze, Esther T.; Ahmed Esmat ; Tadros, Mariane G.; Abdel-Naim, Ashraf B.; Khalifa, Amani E.
371-Feb-2015Synthesis, 3D pharmacophore, QSAR and docking studies of novel quinazoline derivatives with nitric oxide release moiety as preferential COX-2 inhibitorsFarag, Doaa Boshra; Farag, Nahla A.; Ahmed Esmat ; Abuelezz, Sally A.; Abdel-Salam Ibrahim, Eman; Abou El Ella, Dalal 
381-Jan-2015The effect of pomegranate fruit extract on testosterone-induced BPH in ratsAmmar, Amr E.; Ahmed Esmat ; Hassona, Mohammed D.H.; Tadros, Mariane G.; Abdel-Naim, Ashraf B.; Guns, Emma S.Tomlinson
392015Synthesis and in vitro antiproliferative activity of novel pyrazolo[3,4-d]pyrimidine derivativesAbdou, Nermin S.; Serya, Rabah ; Esmat, Ahmed ; Tolba, Mai F.; Ismail, Nasser S. M.; Khaled A M Abouzid 
405-Apr-2014Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosisMantawy, Eman M.; El-Bakly, Wesam M.; Ahmed Esmat ; Badr, Amira M.; El-Demerdash, Ebtehal