Severity of restless leg syndrome in patients undergoing hemodialysis: assessing its burden on quality of life and knowledge
Esraa Samir Mohamed; Hanan Said Ali; Fatma Mostafa Mahrous;
Abstract
Objectives: This study aimed to assess the severity of restless legs syndrome (RLS)
among patients undergoing hemodialysis and to evaluate its burden on quality of
life (QoL), as well as its relationship with knowledge regarding end-stage renal
disease (ESRD), RLS, and hemodialysis (HD).
Methods: In 2025, a descriptive correlation study was used. A purposive sample of
(75) patients was recruited from the hemodialysis unit of Banha University Hospital
in Qalyubia, Egypt. Self-administered questionnaires included: 1) socio
demographic characteristics; 2) a questionnaire assessing patient’s knowledge
regarding ESRD, RLS, and HD; 3) the International Restless Legs Syndrome study
group (IRLSSG) rating scale; and 4) A Quality of life (QoL) scale. Statistical analysis
was analyzed using SPSS version 27.
Results: A total of 75 patients were included, with a mean age of 47.6 ± 9.2 years;
Of them, 65.3% were males, and 56% had been on dialysis for 5–10 years. Overall,
62.7% of the studied patients had an unsatisfactory level of knowledge regarding
ESRD and RLS in the setting of hemodialysis. Regarding RLS severity, 10.7% had
mild, 28.0% had moderate, 42.7% had severe, and 18.6% had very severe RLS.
Overall, 48.0% of participants had poor total QoL. Overall RLS severity and QoL
showed a statistically significant inverse association (p < 0.001). Overall RLS
severity and QoL showed an inverse association with high statistical significance
(p < 0.001). In addition, overall knowledge was inversely associated with overall
RLS severity, though this did not reach statistical significance (p=0.056). However,
QoL showed a statistically significant direct association with the overall level of
knowledge (p < 0.029). Regarding QoL subdimensions, 52.0%, 54.7%, 49.3%, and
37.3% of patients reported poor QoL across the physical, psychological, social,
and spiritual domains, respectively. Overall, 48.0% of participants had poor total
QoL, 37.3% had average QoL, and 14.7% had good QoL.
Conclusion: Among the investigated patients, QoL showed a negative association
with overall RLS severity with high statistical significance. Moreover, overall
knowledge was negatively and meaningfully associated with overall RLS
severity. However, QoL was meaningfully and positively associated with the
overall level of knowledge
among patients undergoing hemodialysis and to evaluate its burden on quality of
life (QoL), as well as its relationship with knowledge regarding end-stage renal
disease (ESRD), RLS, and hemodialysis (HD).
Methods: In 2025, a descriptive correlation study was used. A purposive sample of
(75) patients was recruited from the hemodialysis unit of Banha University Hospital
in Qalyubia, Egypt. Self-administered questionnaires included: 1) socio
demographic characteristics; 2) a questionnaire assessing patient’s knowledge
regarding ESRD, RLS, and HD; 3) the International Restless Legs Syndrome study
group (IRLSSG) rating scale; and 4) A Quality of life (QoL) scale. Statistical analysis
was analyzed using SPSS version 27.
Results: A total of 75 patients were included, with a mean age of 47.6 ± 9.2 years;
Of them, 65.3% were males, and 56% had been on dialysis for 5–10 years. Overall,
62.7% of the studied patients had an unsatisfactory level of knowledge regarding
ESRD and RLS in the setting of hemodialysis. Regarding RLS severity, 10.7% had
mild, 28.0% had moderate, 42.7% had severe, and 18.6% had very severe RLS.
Overall, 48.0% of participants had poor total QoL. Overall RLS severity and QoL
showed a statistically significant inverse association (p < 0.001). Overall RLS
severity and QoL showed an inverse association with high statistical significance
(p < 0.001). In addition, overall knowledge was inversely associated with overall
RLS severity, though this did not reach statistical significance (p=0.056). However,
QoL showed a statistically significant direct association with the overall level of
knowledge (p < 0.029). Regarding QoL subdimensions, 52.0%, 54.7%, 49.3%, and
37.3% of patients reported poor QoL across the physical, psychological, social,
and spiritual domains, respectively. Overall, 48.0% of participants had poor total
QoL, 37.3% had average QoL, and 14.7% had good QoL.
Conclusion: Among the investigated patients, QoL showed a negative association
with overall RLS severity with high statistical significance. Moreover, overall
knowledge was negatively and meaningfully associated with overall RLS
severity. However, QoL was meaningfully and positively associated with the
overall level of knowledge
Other data
| Title | Severity of restless leg syndrome in patients undergoing hemodialysis: assessing its burden on quality of life and knowledge | Authors | Esraa Samir Mohamed ; Hanan Said Ali; Fatma Mostafa Mahrous | Keywords | Egypt, end-stage renal disease, hemodialysis, knowledge, patients, quality of life, restless leg syndrome | Issue Date | 4-Jun-2026 | Publisher | Frontiers | Journal | Frontiers in Nephrology | Volume | Volume 6 - 2026 | Start page | 01 | End page | 10 | DOI | DOI 10.3389/fneph.2026.1850856 |
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