Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation
Naeem, Antoinette G; El-Naga, Reem N.; Effat, Haidy;
Abstract
Multiple sclerosis (MS) is a demyelinating neurodegenerative inflammatory disease affecting mainly young adults. Microgliosis-derived neuroinflammation represents a key hallmark in MS pathology and progression. Nebivolol (Neb) demonstrated antioxidant, anti-inflammatory and neuroprotective properties in several brain pathologies. This study was conducted to investigate the potential neuroprotective effect of Neb in the cuprizone (Cup) model of MS.
Other data
| Title | Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation | Authors | Naeem, Antoinette G; El-Naga, Reem N. ; Effat, Haidy | Keywords | Cuprizone;M1/M2 polarization;Multiple sclerosis;NLRP3;Nebivolol | Issue Date | Dec-2022 | Publisher | SPRINGER BASEL AG | Journal | Inflammopharmacology | Volume | 30 | Start page | 2197 | End page | 2209 | ISSN | 0925-4692 | DOI | 10.1007/s10787-022-01045-4 | PubMed ID | 35948811 | Scopus ID | 2-s2.0-85135848226 | Web of science ID | WOS:000840564100003 |
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