Synthesis and biological evaluation of new thiazolopyrimidines
Said, Makarem; Abouzid, Khaled; Mouneer, Ashraf; Ahmedy, Ali; Osman, Abdel Moneim;
Abstract
In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones (1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-methylthiazolo[5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones (4-6, 10) and 3-benzyl-5-methyl thiazolo[5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones (7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.
Other data
| Title | Synthesis and biological evaluation of new thiazolopyrimidines | Authors | Said, Makarem; Abouzid, Khaled ; Mouneer, Ashraf; Ahmedy, Ali; Osman, Abdel Moneim | Keywords | Antimicorbial activity;Antitumor activity;Thiazolopyrimidines | Issue Date | May-2004 | Journal | Archives of pharmacal research | Volume | 27 | Start page | 471 | End page | 477 | ISSN | 0253-6269 | DOI | 10.1007/BF02980118 | PubMed ID | 15202550 | Scopus ID | 2-s2.0-16544362716 |
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