Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines
Abouzid, Khaled; Khalil, NA; Ahmed, E.M.;
Abstract
A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 μmol. © Springer Science+Business Media, LLC 2011.
Other data
| Title | Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines | Authors | Abouzid, Khaled ; Khalil, NA; Ahmed, E.M. | Keywords | Breast cancer;Anti-proliferative activity;Phthalazine;Phthalazinone;KINASE INHIBITOR;BREAST-CANCER;AGENTS;ANTAGONISTS | Issue Date | 2012 | Publisher | SPRINGER | Journal | Medicinal Chemistry Research | Volume | 21 | Start page | 3288 | End page | 3293 | ISSN | 1054-2523 | DOI | 10.1007/s00044-011-9874-z | Scopus ID | 2-s2.0-84866371621 | Web of science ID | WOS:000307995200061 |
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