The adverse effects of bisphenol A on male albino rats

Abstract

Background: Bisphenol A (BPA) is a monomer used in the production of a multitude of chemical products, including epoxy resins and polycarbonates. The purpose of this study was to consider the biochemical, histological, genetic, and molecular alterations induced by BPA in adult male albino rats. They were orally subjected to BPA (20 and 100 mg/kg body weight) mixed in olive oil once a day for 30 days. At the end of the experiment, liver, testis, serum, and bone marrow were collected. Result: A significant increase in the level of malondialdehyde (MDA), with a significant decline in the content of superoxide dismutase (SOD) and reduced glutathione (GSH) in rats’ livers and testes after administration of both doses of BPA occurred. Also, there was a significant decrease in the testosterone activity in both treated groups. Histopathologic effects of bisphenol A on livers and testes of male rats showed that the treatment with both doses of BPA resulted in deleterious effects on livers and testes. The frequency of the micronucleus (MN) in polychromatic erythrocytes (PCEs) in bone marrow cells at both doses was significantly increased as compared to control group, while no changes were observed in polychromatic erythrocytes/normochromatic erythrocytes (PCEs/NCEs) ratio. Finally, BPA caused a suppressive effect on spermatogenesisassociated 7 (SPATA 7) gene in a dose-dependent manner. Conclusion: Exposure of rats to both selective doses of BPA leads to many adverse effects on liver and testis tissues. Also, an increase in frequency of the micronucleus in bone marrow cells was shown and suppression in the expression of SPATA 7 gene.