Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines
Nadia G. Kandile, and Hind M. Ismaeel; ismail, mansoura;
Abstract
New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)
hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were
characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxicity evaluation of HL
5a and the new complexes showed that these complexes could act as anticancer agents since they reduced the
growth of samples of human tumour cell lines (HCT116(Colon), MCF7(Breast) and HELA(Cervix)) to ≤18.5 μg/mL for the new
complexes.
hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were
characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxicity evaluation of HL
5a and the new complexes showed that these complexes could act as anticancer agents since they reduced the
growth of samples of human tumour cell lines (HCT116(Colon), MCF7(Breast) and HELA(Cervix)) to ≤18.5 μg/mL for the new
complexes.
Other data
| Title | Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines | Authors | Nadia G. Kandile, and Hind M. Ismaeel ; ismail, mansoura | Keywords | Hyrazone ligands, 5-substituted isatins, cytotoxicity, anticancer drugs | Issue Date | 14-May-2012 | Publisher | Taylor & Francis | Journal | Journal of Enzyme Inhibition and Medicinal Chemistry | DOI | 10.3109/14756366.2011.588950 |
Recommend this item
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.