Abouzid, Khaled

khaled.abouzid@pharma.asu.edu.eg

Department of Pharmaceutical Chemistry - Pharmacy
Interests: Anticancer drug discovery, design and synthesis, Antimicrobial,
Internal ID: rp12178
  • 2,885 Scopus Citations
  • 592 PubMed Citations

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Full Name
Abouzid, Khaled
 
 
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Biography
Dr. Khaled Abouzid is a Professor of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Prominent Scholar in Drug Discovery, Co-founding Director of Center of Drug Discovery and Development Research ASU He was nominated as the Acting Dean of the Faculty of Pharmacy, University of Sadat City from 8-2018 to 8-2022. He is currently a member of national pharmaceutical chemistry promotion committee
Dr. Abouzid’s research is directed towards drug discovery of bioactive small molecules with special emphasis on cannabinoids, targeted anticancer, anti-inflammatory, anti-viral anti-microbial agents and enzyme inhibitors. He has published over 150 research papers, two books and filed 14 patents in medicinal chemistry. He has Scopus H index of 28. He has supervised over 100 Master and PhD students in 7 universities. Dr Abouzid has research collaborations with German, British, Swedish, Canadian and US universities. He has also organized and presided over 34 international symposia and conferences.
Dr. Abouzid obtained his B.Sc. degree in Pharmaceutical Sciences from Cairo University in 1985, and his PhD. joint degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University and School of Pharmacy University of Connecticut, USA.
Dr. Abouzid started his career in 1995 as a lecturer of Organic Chemistry at Cairo University, Faculty of Pharmacy. In 2001, he moved to the Department of Pharmaceutical Chemistry, Ain Shams University, and was promoted to Associate Professor in 2003. He did postdoctoral work with Professor Jochen Lehman of the Friedrich-Schiller-Universität Jena, Germany.

Publications

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Issue DateTitleAuthor(s)
211-Sep-2020An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic propertiesMohamed, Sameh H; Elgiushy, Hossam R; Hammad, Sherif F; Abou-Taleb, Nageh A; A M Abouzid, Khaled; Abouzid, Khaled ; Hassan, Zeinab; Ali Taha, Heba
2226-Aug-2020Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancerMansour, Mai A; Lasheen, Deena S. ; Gaber, Hatem M; Khaled A M Abouzid 
2318-Aug-2020Design, Synthesis, and Biological Evaluation of Novel 7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazine Inhibitors as Antitumor AgentsIsmail, Muhammad I; Mohamady, Samy; Samir, Nermin; Abouzid, Khaled 
2410-Aug-2020Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitorsRamadan, Sayed ; Elrazaz, Eman ; Khaled A M Abouzid ; El- naggar, Abeer 
25Aug-2020Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitorsHadi, Soha R Abd El; Soliman, Dalia H; Elrazaz, Eman ; Khaled A M Abouzid ; Lasheen, Deena S. 
6Jan-2020Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell linesSalem, Mohamed S H; Abdel Aziz, Yasmine M; Elgawish, Mohamed S; Said, Mohamed M; Abouzid, Khaled 
7Jan-2020Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-onesHammad, Shaymaa G; El-Gazzar, Marwa G; Abutaleb, Nader S; Li, Daoyi; Ramming, Isabell; Shekhar, Aditya; Abdel-Halim, Mohammad; Elrazaz, Eman ; Seleem, Mohamed N; Bilitewski, Ursula; El-Hossary, Ebaa M; Khaled A M Abouzid 
82020Synthesis, Biological Evaluation and In Silico Investigation of Novel Functionalized Imidazole-Based KDM6 InhibitorsSerya, Rabah ; El-Araby, Amr; Qassem, Omar; El-Sawy, Ezzat; El-Razaz, Eman; Abouzid, Khaled 
91-Dec-2019Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancerElmenier, Fatma M; Lasheen, Deena S. ; Khaled A M Abouzid 
10Aug-20193D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluationSobhy, Mahitab K; Mowafy, Samar; Lasheen, Deena S. ; Farag, Nahla A; Khaled A M Abouzid 
1125-Mar-2019Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic InducersEl Newahie, Aliya M S; Nissan, Yassin M; Ismail, Nasser S M; Abou El Ella, Dalal ; Khojah, Sohair M; Abouzid, Khaled 
12Mar-2019Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agentsGhith, Amna; Youssef, Khairia M; Ismail, Nasser S M; Abouzid, Khaled 
1313-Nov-2018Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axisGe, Xin; Pan, Min-Hong; Wang, Lin; Li, Wei; Jiang, Chengfei; He, Jun; Abouzid, Khaled ; Liu, Ling-Zhi; Shi, Zhumei; Jiang, Bing-Hua
14Sep-2018Pyrrolopyrimidine, A Multifaceted Scaffold in Cancer Targeted TherapyAdel, Mai; Serya, Rabah A T; Lasheen, Deena S. ; Abouzid, Khaled 
15Sep-2018Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancerHesham, Heba M; Lasheen, Deena S. ; Khaled A M Abouzid 
1615-Jul-2018Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinomaShahin, Mai I; Roy, Joyeeta; Hanafi, Maha; Wang, Dongyao; Luesakul, Urarika; Chai, Yifeng; Muangsin, Nongnuj; Lasheen, Deena S. ; Neamati, Nouri; Khaled A M Abouzid ; Abou El Ella, Dalal 
171-Jun-2018Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agentsFawzy, Iten M; Youssef, Khairia M; Lasheen, Deena S. ; Ismail, Nasser Sm; Abouzid, Khaled 
182018Acrylamide moiety, a Valuable Fragment in Medicinal Chemistry: Insight into Synthetic Methodologies, Chemical Reactivity and Spectrum of Biological Activities of Acrylamide DerivativesElgiushy, Hossam; Hammad, Sherif; Hassan, Ashraf; Aboutaleb, Nageh; Abouzid, Khaled 
192018Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (HDACi) and anticancer agentsHesham, Heba; Lasheen, Deena S. ; Abouzid, Khaled 
20Nov-2017Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting Tyrosine Kinases and Their Potential Anticancer ActivitiesGhith, Amna; Ismail, Nasser S M; Youssef, Khairia; Abouzid, Khaled